Best Poster Award to DBT Supported PhD Scholar

We are thrilled to announce that Premananda Ghosh, one of our Department of Biotechnology (DBT) supported PhD scholars, has been awarded the prestigious Best Poster Award at the 30th International Conference on Organometallic Chemistry (ICOMC 2024), held from July 14th to 18th in Agra, India.

We are proud to see our researchers making impactful contributions on global platforms, representing the IITB-Monash Research Academy and pushing the boundaries of knowledge in the field of organometallic chemistry.

We would also like to congratulate Premananda and his supervisory team for publishing a paper in Nature Communications.

Publication details:

Tandem dehydrogenation-olefination-decarboxylation of cycloalkyl carboxylic acids via multifold C–H activation

Link: https://www.nature.com/articles/s41467-024-49359-x

Summary:

The dehydrogenation chemistry of aliphatic carboxylic acids is fascinating, especially the way Prof. Debabrata Maiti and his team managed to develop a catalytic system that enables these acids to undergo such a complex sequence of reactions involving- dehydrogenation, olefination, decarboxylation, and aromatization. The bypassing of lactone formation and the selective formation of olefinated arenes from cyclohexane carboxylic acid is particularly noteworthy. The ability to control the reaction to achieve either aromatization or difunctionalized products depending on the substrate structure is a significant contribution to the field.

This work provides a versatile method for the functionalization of various carboxylic acids, leading to products with new chemical identities and broad applications. This research could open up new avenues in aliphatic carboxylic acids, which has historically been a challenging area. By isolating key intermediates and performing control experiments, the research showcases a profound understanding of the reaction mechanism, underscoring its importance in advancing the field of organic synthesis and medicinal chemistry.